Detergents modify proteinase K resistance of PrPSc in different transmissible spongiform encephalopathies (TSEs)
نویسندگان
چکیده
منابع مشابه
Transmissible Spongiform Encephalopathies
Neuronal death represents the primary pathology of neurodegenerative diseases such as Alzheimer's and Parkinson’s disease and Amyotrophic Lateral Sclerosis. These diseases usually present with a slow onset and a chronic progression. Various regions of the brain, spinal cord, or peripheral nerves may be affected, leading to functional impairment and neuron loss. Neurodegenerative diseases are of...
متن کاملHuman Transmissible Spongiform Encephalopathies
Creutzfeldt-Jakob disease (CJD) is a rare and fatal human neurodegenerative condition characterized in most cases by a rapidly progressive dementia, myoclonus, and a periodic electroencephalogram (EEG). It is classified as a transmissible spongiform encephalopathy (TSE) because it causes characteristic spongy degeneration of the brain and can be transmitted to laboratory animals. TSEs also affe...
متن کاملTransmissible spongiform encephalopathies
Keywords Disease name and synonyms Included diseases Definition Pathogenesis Sporadic CJD Genetic forms of TSE Acquired forms of TSE Treatment Conclusion References Abstract Human prion diseases or transmissible spongiform encephalopathies (TSE) are rare transmissible diseases affecting the central nervous system. The infectious agents are composed of an abnormal isoform of a host membrane prot...
متن کاملTransmissible spongiform encephalopathies.
Vet Med Today: Zoonosis Update 1705 T spongiform encephalopathies affect humans and other animals. Clinically, the diseases involve severe, progressive neurodegeneration with an invariably fatal outcome. The TSEs are linked by the unusual nature of their causative agent, which is believed to be a transmissible protein devoid of nucleic acid. This protein, known as a prion (a pseudoabbreviation ...
متن کاملTransmissible spongiform encephalopathies in humans.
Creutzfeldt-Jakob disease (CJD), the first transmissible spongiform encephalopathy (TSE) to be described in humans, occurs in a sporadic, familial, or iatrogenic form. Other TSEs in humans, shown to be associated with specific prion protein gene mutations, have been reported in different parts of the world. These TSEs compose a heterogeneous group of familial diseases that traditionally have be...
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ژورنال
عنوان ژورنال: Veterinary Microbiology
سال: 2012
ISSN: 0378-1135
DOI: 10.1016/j.vetmic.2011.12.008